Abstract: Nurses are an important part of the any healthcare team who play a unique role in the control of Hospital acquired infections. In treatment centres and hospitals around the world, nosocomial infections are very common causing major risks and complications that even leads to the death of patients. Several preventive measures have been attempted to prevent hospital acquired infections to increase the safety and well-being of the patients. Despite many preventive approaches implemented to reduce the microbial contamination, the infection remains to cause serious complications and increase hospital stay and treatment cost. Effective nursing practices with appropriate control measures have contributed to a substantial reduction in the incidence of hospital acquired pathogens. Nurses can effectively prevent infection from occurring with prudential measures such as “hand hygiene, skin disinfection, wearing masks and gloves to prevent the spread of infection, infusion set change, following standard caution principles, averting inadvertent contact with needle stick, preventing from the exposure to respiratory discharges”. Their practices concerning hygienic environment play a crucial role to assure patients health by controlling the infections.